What is Entresto (sacubitril/valsartan) for?

Buy Entresto (sacubitril/valsartan). Entresto (sacubitril/valsartan) is a special medicine. It’s used to treat:

• adults with long-lasting (chronic) heart failure to help reduce the risk of death and hospitalization.
• pediatric patients aged one year and older with symptomatic heart failure who have systemic left ventricular systolic dysfunction

This medicine is best for people whose heart can’t pump enough blood.

It comes in tablet form. Each tablet has 24 mg/26 mg, 49 mg/51 mg, or 97 mg/103 mg sacubitril/valsartan.

How does Entresto (sacubitril/valsartan) work?

Entresto has two main parts: sacubitril and valsartan. They work differently on the heart.

Sacubitril stops the breakdown of natriuretic peptides. These peptides help the body get rid of sodium and water. This reduces the heart’s workload. They also lower blood pressure and protect the heart from scarring.

Valsartan blocks the hormone angiotensin II. This hormone can harm the heart in patients with heart failure. By blocking its receptor, valsartan reduces the heart damage. It also helps blood vessels relax, lowering blood pressure.

Where has Entresto (sacubitril/valsartan) been approved?

Entresto (sacubitril/valsartan) has been approved by:

• The Food and Drug Administration (FDA), USA:
  • On July 7, 2015 to treat heart failure in adults.
  • On October 1, 2019 to treat pediatric heart failure.
  • On February 16, 2021 to treat chronic heart failure.
• The European Medicines Agency (EMA):
  • On November 19, 2015 to treat heart failure in adults.
  • On September 11, 2019 to treat pediatric heart failure.
• National Medical Products Administration (NMPA), China:
  • In 2017 to treat heart failure.
  • On June 10, 2021 to treat hypertension.

It’s approved in 115 countries worldwide for heart failure with reduced ejection fraction.

This medicine might be approved in other places too. If you have questions, contact our support team.

How is Entresto (sacubitril/valsartan) taken?

The usual dose is:

• The starting dose is one tablet of Entresto 49 mg/51 mg twice daily
• After 2 to 4 weeks, the dose is doubled to 97 mg / 103 mg twice daily.

The doctor might give lower doses to some patients.

It’s often used with other heart failure treatments. It’s a top choice for heart failure with reduced ejection fraction.

Entresto may change how other medicines work. Other medicines might also affect it. Always tell your doctor about all medicines you take.

Warning: you should not take an ACE inhibitor medicine and Entresto together. Do not take this medicine when you have a history of angioedema or liver disease.

Kidney function and blood potassium levels will be checked regularly.

Complete information about Entresto (sacubitril/valsartan) dosage and administration is in our references section.

Note: Please consult with your treating doctor for personalised dosing.

Are there any known adverse reactions or side effects of Entresto (sacubitril/valsartan)?

Common adverse reactions

The most common side effects (≥5% of patients) include:

• Low blood pressure (hypotension)
• Kidney problems
• Increased levels of potassium in your blood (hyperkalemia)
• Dizziness

Serious adverse reactions

The serious adverse reactions include:

• Serious allergic reactions

Use in a specific population

Entresto (sacubitril/valsartan) can be fatal for a fetus. It’s advised to avoid pregnancies and breastfeeding.

For a comprehensive list of side effects and adverse reactions, please refer to the official prescribing information.