Buy Ondexxya (andexanet alfa)

What is Ondexxya (andexanet alfa) for?

Buy Ondexxya (andexanet alfa). Ondexxya (andexanet alfa) is a drug used to reverse the effects of certain blood thinners. It’s for patients on rivaroxaban and apixaban when they need quick action to stop severe bleeding.

It comes in a powder form, in vials of 200 mg or 100 mg.

How does Ondexxya (andexanet alfa) work?

Factor Xa inhibitors like apixaban and rivaroxaban prevent blood clots. They work by blocking a protein called FXa. But, they can cause major bleeding.

Ondexxya binds to these inhibitors, stopping their blood-thinning effect. This helps stop bleeding quickly.

Where has Ondexxya (andexanet alfa) been approved?

Ondexxya has been approved in several places:

• The European Medicines Agency (EMA), Europe, on April 26, 2019.
• The Food and Drug Administration (FDA), USA, with accelerated approval under the brand name Andexxa (coagulation factor Xa (recombinant), inactivated-zhzo) on May 3, 2018.

This is the first antidote for apixaban- or rivaroxaban-treated patients with uncontrolled bleeding.

The EMA approved it under conditional marketing authorisation. This allows early access to medicines in the European Union.

The FDA gave Andexxa Orphan Drug and Breakthrough Therapy designations. These designations support medicines for serious conditions and unmet needs.

This medicine might be approved in other regions too. If you have questions, contact our support team.

How is Ondexxya (andexanet alfa) taken?

The standard dosage is:

• • Low dose:
    • 400 mg, administered as an intravenous bolus at a target rate of 30 mg/min.
    • Followed by administration of a continuous infusion of 4 mg/min for up to 120 minutes (480 mg).
  • High dose:
    • 800 mg, administered as an intravenous bolus at a target rate of 30 mg/min.
    • Followed by administration of a continuous infusion of 8 mg/min for 120 minutes (960 mg).

The dosage depends on the FXa inhibitor, its dose, and when the patient last took it.

Patients on anticoagulants are at risk of blood clots. Using Ondexxya increases this risk. Doctors should consider restarting anticoagulants when safe.

For more details on dosage and administration, see the official prescribing information in our references section.

Note: Please consult with your treating doctor for personalised dosing.

Are there any known adverse reactions or side effects of Ondexxya?

Common adverse reactions

The most common side effects (≥5% of patients) include:

• • • Urinary tract infections
    • Pneumonia

Serious adverse reactions

Here are the serious side effects listed:

• • • Arterial and venous thromboembolic events
    • Ischemic events, including myocardial infarction and ischemic stroke
    • Cardiac arrest
    • Sudden deaths

Use in a specific population

It’s not clear if Ondexxya affects unborn babies. The maker doesn’t suggest using it during pregnancy.

For a full list of side effects and adverse reactions, see the official prescribing information.

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