Buy Oxlumo (lumasiran)

What is Oxlumo (lumasiran) for?

Buy Oxlumo (lumasiran). Oxlumo (lumasiran) is a medicine for a rare disease called primary hyperoxaluria type 1 (PH1). It helps lower oxalate levels in urine for adults and children.

It comes in an injection form. Each vial has 94.5 mg/0.5 mL of lumasiran.

How does Oxlumo (lumasiran) work?

PH1 is a rare disease where the liver makes too much oxalate. This can harm the kidneys and lead to failure.

Lumasiran works by targeting the HAO1 gene. This gene is linked to the production of oxalate.

It’s a small interfering RNA (siRNA). It silences the HAO1 gene. This stops the production of oxalate, bringing levels back to normal.

Where has Oxlumo (lumasiran) been approved?

Oxlumo (lumasiran) is approved for PH1 in all ages by:

• The European Medicines Agency (EMA), on November 19, 2020.
• The Food and Drug Administration (FDA), on November 24, 2020.

It’s the first approved treatment for PH1 to lower urine oxalate levels.

Oxlumo (lumasiran) also got Breakthrough Therapy Designation from FDA and Priority Medicines (PRIME) Designation from EMA. It has Orphan Drug Designations from both FDA and EMA.

This medicine might be approved in other places too. If you have questions about its approval in a specific country, contact our support team.

 

How is Oxlumo (lumasiran) taken?

The standard dosage:

• Given as an under-the-skin (subcutaneous) injection once a month for 3 months
• Then monthly for those weighing less than 10 kg, and quarterly for those weighing more than 10 kg.

Dosing depends on body weight. The dose and volume are calculated as follows:

• Patient body weight (kg) × dose (mg/kg) = total amount (mg) of lumasiran to be administered.
• Total amount (mg) / concentration (189 mg/mL) = total volume of lumasiran solution (mL) to be injected.

For more details on dosage and administration, see the official prescribing information in our references section.

Note: Please consult with your treating doctor for personalized dosing.

Are there any known adverse reactions or side effects of Oxlumo (lumasiran)?

Common adverse reactions

The most common side effects (≥10% of patients) include:

• • Injection site reactions
  • Stomach pain or discomfort (abdominal pain)

Use in a specific population

Oxlumo (lumasiran) can harm a fetus if given to a pregnant woman. It’s advised to avoid pregnancies and breastfeeding.

For a full list of side effects and adverse reactions, see the official prescribing information.

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