Buy Symdeko (tezacaftor / ivacaftor)

What is Symdeko (tezacaftor/ivacaftor)?

Buy Symdeko (tezacaftor / ivacaftor). Symdeko (tezacaftor/ivacaftor)* is a medicine for cystic fibrosis (CF) patients aged 6 and up. It comes in tablets with 100 mg of tezacaftor and 150 mg of ivacaftor. It’s used with another ivacaftor-only medicine.

In Europe, it’s known as Symkevi, and in the U.S., as Symdeko.

Each tablet has 100 mg of tezacaftor and 150 mg of ivacaftor.

Who is Symdeko (tezacaftor/ivacaftor)* for?

Symdeko (tezacaftor/ivacaftor)* is for CF patients aged 6 and up. They must have two F508del mutations or one responsive mutation.

Patients should talk to their doctor to check if they have the right mutation.

How does Symdeko (tezacaftor/ivacaftor)* work?

Cystic Fibrosis (CF) causes thick mucus in lungs and digestive tract. This leads to breathing and digestive issues, infections, and diabetes. It’s caused by CFTR gene mutations.

These mutations affect the CFTR protein, making mucus and juices thick. Symdeko (tezacaftor/ivacaftor)* fixes this by boosting CFTR protein and activity.

This makes ion transport normal, reducing mucus thickness.

Where has Symdeko (tezacaftor/ivacaftor)* been approved?

Symdeko (tezacaftor/ivacaftor)* was approved for CF treatment in several places:

• Health Canada, June 28, 2018, commercialised under the brand name Symdeko
• European Medical Agency (EMA), European Union, October 31, 2018, commercialised under the brand name Symkevi
• Food and Drug Administration (FDA), USA, December 2, 2018, commercialised under the brand name Symdeko. This indication was extended on December 21, 2020 for use in patients who have two copies of the F508del mutation, or who have at least one mutation in the CF gene that is responsive to treatment with Symdeko.
• Therapeutic Goods Administration (TGA), Australia, March 5, 2019, commercialised under the brand name Symdeko.

This medicine might be approved in other places too. If you have questions, contact our support team.

How is Symdeko (tezacaftor/ivacaftor)* taken?

The standard dosage is:

• A combination regimen with ivacaftor 150 mg tablets
• Taken orally twice a day
• One tablet every 12 hours with fat containing food

For patients with moderate or severe liver problems, the dose might need to be lowered. If you’re taking strong CYP3A inhibitors, you’ll need to take only one Symdeko (tezacaftor/ivacaftor)* tablet twice a week. This should be about 3 to 4 days apart. Also, skip the evening dose of ivacaftor.

It’s important to avoid strong CYP3A inhibitors and inducers while on Symdeko (tezacaftor/ivacaftor)*. For more details on dosage and how to take it, see the official prescribing information in our references section.

Note: Always talk to your doctor about the right dose for you and any possible drug interactions.

Are there any known side effects or adverse reactions of Symdeko (tezacaftor/ivacaftor)*?

The most common side effects include:

• headache
• nasopharyngitis (upper respiratory infection)
• dizziness
• sinus congestion.

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