Buy Zokinvy (lonafarnib)

What is Zokinvy (lonafarnib) for?

Buy Zokinvy (lonafarnib). Zokinvy (lonafarnib) is a drug that helps reduce the risk of death in certain cases. It is used for:

• Adults and children aged 12 months or older with Hutchinson-Gilford Progeria Syndrome (HGPS), who have a certain body surface area
• Adults and children 12 months of age or older with certain types of Progeroid Laminopathies, who have a certain body surface area

Zokinvy (lonafarnib) is not for use in people with non-HGPS Progeroid Syndromes or with Progeroid Laminopathies that are processing-proficient.

It comes in capsule form, with 50 mg or 75 mg of lonafarnib.

How does Zokinvy (lonafarnib) work?

Patients with HGPS and progeroid laminopathies have a buildup of broken progerin or progerin-like protein in their cells. Progerin is a defective version of the protein Lamin A. It’s important for cell protection and longevity.

Lonafarnib is a farnesyltransferase inhibitor. It prevents the buildup of defective progerin or progerin-like protein. Farnesyltransferase is an enzyme involved in protein adjustment through prenylation.

Lonafarnib blocks prenylation of progerin. This prevents the production and buildup of broken progerin.

Where has Zokinvy (lonafarnib) been approved?

Zokinvy (lonafarnib) was approved for treating Progeria and Progeroid Laminopathies by:

• The Food and Drug Administration (FDA), on November 20, 2020.

It’s the first FDA-approved medicine for these diseases.

Zokinvy (lonafarnib) received Orphan Drug designation from the FDA and the European Medicines Agency (EMA). It also got Priority Review and Breakthrough Therapy Designation. Plus, it received a rare pediatric disease priority review voucher.

Please note that this medicine may have also been approved in other regions than the ones we’ve listed. If you have a question about its approval in a specific country feel free to contact our support team.

 

 

How is Zokinvy (lonafarnib) taken?

The standard dosage is:

• Based on body size (height and weight). The treating doctor will determine the dose to be taken.

Zokinvy (lonafarnib) capsules should be taken by mouth (orally) 2 times a day, with morning and evening meals. The capsules should be swallowed whole, with plenty of water.

If the patient is unable to swallow the capsule whole, see the detailed instructions in the official prescribing information. The contents of the capsules can be mixed with either Ora Blend SF, Ora-Plus, orange juice, or applesauce. The freshly prepared mixture should be taken within about 10 minutes of mixing.

Zokinvy (lonafarnib) cannot be taken with any juice that contains grapefruit or Seville oranges (also called bitter or sour oranges).

Because it can interact with other medicines, Zokinvy (lonafarnib) should not be taken together with a strong or moderate CYP3A inhibitor or inducer, as well as midazolam and certain cholesterol-lowering medications.

Complete information about Zokinvy (lonafarnib) dosage, administration and possible drug interactions can be found in the official prescribing information.

Note: Please consult with your treating doctor for personalised dosing.

Are there any known adverse reactions or side effects of Zokinvy (lonafarnib)?

Common adverse reactions

The most common side effects (≥10% of patients) listed in the prescribing information include:

• Vomiting
• Diarrhea
• Infection
• Nausea
• Decreased appetite
• Tiredness
• Upper respiratory tract infection
• Stomach-area (abdominal) pain
• Muscle and joint (musculoskeletal) pain
• Electrolyte abnormalities
• Decreased weight
• Headache
• Myelosuppression
• Increased liver enzyme blood test results
• Decreased blood bicarbonate
• Cough
• Increased blood pressure (hypertension)

Serious adverse reactions

The serious adverse reactions listed in the prescribing information include:

• Severe kidney problems
• Eye problems

Use in a specific population

Zokinvy (lonafarnib) may cause fertility problems in men and women. This could affect your ability to have children. If you have concerns about fertility, talk to your doctor.

The medicine can cause harm to a fetus if given to a pregnant woman. It’s advised to avoid pregnancies and breastfeeding.

For a comprehensive list of side effects and adverse reactions, please refer to the official prescribing information.

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